Research synopsis
The blood barriers of the nervous system protect and ensure homeostatic balance within nervous tissue while at the same time impairing therapeutic delivery. My main research interest is to uncover how the blood nerve barrier in the peripheral nerve is conferred by its microenvironment. The structure and regulation of the blood nerve barrier is still poorly understood despite the importance of the barrier for PNS function, with disruption associated with disorders such as diabetes and neuropathies.
To study the blood nerve barrier, we use a combination of imaging and molecular approaches to characterise it and uncover the mechanisms by which the barrier is conferred.
Biography
2018-2019 MSc Neuroscience at UCL
2015-2018 Biomedical Science at University of Fribourg, Switzerland
Funders
Cancer Research UK
Research themes
Signaling pathways
Cell-cell interactions
Microenvironment
Blood neural barriers
Technology
Electron microscopy
Light microscopy
Super-resolution microscopy
Light sheet microscopy
Image analysis; IMARIS, Amira