Harry Horsnell

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PhD Student, Acton Lab

harry.horsnell.17@ucl.ac.uk

Europe PMC | PubMed | LinkedIn | ORCID

Research synopsis

The fundamental question of my research is how do mechanics control expansion of the Lymph node during inflammation. In particular how a cellular network called the fibroblastic reticular cell network alters its cell intrinsic mechanics and responds to external mechanical cues during expansion of the Lymph node. Using in vitro and in vivo models I have used and established a number of techniques to probe the mechanical nature of the FRC network and begun to understand the function of mechanics in the tissue for controlling lymph node expansion. This work may allow us to understand new cellular pathways that we could target to boost or suppress immunity in a variety of physiological and pathophysiological processes.

Biography

2016-2017 | Lab technician, Genesys Biotech, UK

2012-2016 | University of Bath, 1st class BSc Hons in Biochemistry, UK

2014-2015 | Research Placement, The Garvan Institute of Medical Research, Sydney, Australia

Funders

Medical Research Council

Research themes

Biophysics

Stromal immunology

Cell-cell communication

Technology

Optical tweezers

Confocal microscopy

Micropatterning

Tissue sectioning

Osmotic shock assays

In vivo mouse models

Ex vivo lymph node cultures

Laser ablation

Time-lapse microscopy