My research focuses on the lymph node, which is a critical component of the immune system and plays an essential role in the immune response to infections and cancer. Fibroblastic reticular cells, a type of cell within the lymph node, are responsible for providing structural support and organizing the extracellular matrix. They also interact with immune cells, aiding their function. Although fibroblasts are known to act as mechanosensors, the mechanical forces governing their behaviour within the lymph node are not well understood.
To address this gap in knowledge, my research project involves using Python to develop a model of mechanical forces governing lymph node expansion and the role of fibroblasts in this process. By gaining a better understanding of the behaviour of fibroblasts within the lymph node, we can uncover how cancer cells may exploit these mechanical forces to promote metastasis.
Overall, this research project has the potential to advance our understanding of the immune system and cancer biology, paving the way for the development of novel therapeutic strategies for cancer treatment.